Inhibition of poly(ADP-ribose) polymerase attenuates ischemic renal injury in rats.

@article{Martn2000InhibitionOP,
  title={Inhibition of poly(ADP-ribose) polymerase attenuates ischemic renal injury in rats.},
  author={Daniel Rodr{\'i}guez Mart{\'i}n and Andrew J P Lewington and Mare R. Hammerman and Babu J Padanilam},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2000},
  volume={279 5},
  pages={
          R1834-40
        }
}
The enzyme, poly(ADP-ribose) polymerase (PARP), effects repair of DNA after ischemia-reperfusion (I/R) injury to cells in nerve and muscle tissue. However, its activation in severely damaged cells can lead to ATP depletion and death. We show that PARP expression is enhanced in damaged renal proximal tubules beginning at 6-12 h after I/R injury. Intraperitoneal administration of PARP inhibitors, benzamide or 3-amino benzamide, after I/R injury accelerates the recovery of normal renal function… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 46 CITATIONS

A metabolomic study of low estimated GFR in non-proteinuric type 2 diabetes mellitus

  • Diabetologia
  • 2011
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Molecular Mechanisms of Necrotic Cell Death in Ischemic Renal Injury

VIEW 6 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Cell death induced by acute renal injury: a perspective on the contributions of apoptosis and necrosis.

  • American journal of physiology. Renal physiology
  • 2003
VIEW 13 EXCERPTS
CITES BACKGROUND & RESULTS

Immune mechanisms in the different phases of acute tubular necrosis

  • Kidney research and clinical practice
  • 2018
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 35 REFERENCES

Treatment of acute renal failure.

  • Kidney international
  • 1998
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 1997
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Mechanisms of ischemic acute renal failure.

  • Kidney international
  • 1993
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL