Inhibition of poly(adenosine diphosphate-ribose) polymerase by the active form of vitamin D.

@article{Mabley2007InhibitionOP,
  title={Inhibition of poly(adenosine diphosphate-ribose) polymerase by the active form of vitamin D.},
  author={Jon G. Mabley and Rebecca Wallace and P{\'a}l Pacher and Kanneganti Murphy and Csaba Szab{\'o}},
  journal={International journal of molecular medicine},
  year={2007},
  volume={19 6},
  pages={947-52}
}
Vitamin D is well characterized for its role in mineral homeostasis and maintenance of normal skeletal architecture. Vitamin D has been demonstrated to exert anti-inflammatory effects in a variety of disease states including diabetes, arthritis and inflammatory bowel disease. In these diseases poly[adenosine diphosphate (ADP)-ribose] polymerase (PARP) inhibitors have also proved effective as anti-inflammatory agents. Here we present data demonstrating that the active metabolite of vitamin D… CONTINUE READING
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