Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.

  title={Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers.},
  author={Peter C.C. Fong and David S. Boss and Timothy Anthony Yap and Andrew N. J. Tutt and Pei Jun Wu and Marja W. J. Mergui-Roelvink and Peter S. Mortimer and Helen C. Swaisland and Alan Lau and Mark J. O’Connor and Alan Ashworth and James Carmichael and Stanley B. Kaye and Jan H. M. Schellens and Johann S. de Bono},
  journal={The New England journal of medicine},
  volume={361 2},
BACKGROUND The inhibition of poly(adenosine diphosphate [ADP]-ribose) polymerase (PARP) is a potential synthetic lethal therapeutic strategy for the treatment of cancers with specific DNA-repair defects, including those arising in carriers of a BRCA1 or BRCA2 mutation. We conducted a clinical evaluation in humans of olaparib (AZD2281), a novel, potent, orally active PARP inhibitor. METHODS This was a phase 1 trial that included the analysis of pharmacokinetic and pharmacodynamic… 

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