Inhibition of poly(ADP-ribose) polymerase attenuates cerebral vasospasm after subarachnoid hemorrhage in rabbits.

@article{Satoh2001InhibitionOP,
  title={Inhibition of poly(ADP-ribose) polymerase attenuates cerebral vasospasm after subarachnoid hemorrhage in rabbits.},
  author={Masataka Satoh and Ichiro Date and Mizue Nakajima and Kouki Takahashi and Keiichi Iseda and Takashi Tamiya and Takashi Ohmoto and Yoshihiko Ninomiya and S Asari},
  journal={Stroke},
  year={2001},
  volume={32 1},
  pages={225-31}
}
BACKGROUND AND PURPOSE Poly(ADP-ribose) polymerase (PARP) is important in modulating inflammation, which has been implicated in cerebral vasospasm after subarachnoid hemorrhage (SAH). We investigated the role of PARP in vasospasm using 3-aminobenzamide (3-AB), a PARP inhibitor, in a rabbit model. METHODS Twenty-four New Zealand White rabbits were divided into 4 groups: (1) no treatment (control group, n=6); (2) blood injection without pretreatment (SAH-only group, n=6); (3) blood injection… CONTINUE READING