Inhibition of poliovirus-induced cleavage of cellular protein PCBP2 reduces the levels of viral RNA replication.

@article{Chase2014InhibitionOP,
  title={Inhibition of poliovirus-induced cleavage of cellular protein PCBP2 reduces the levels of viral RNA replication.},
  author={Amanda J. Chase and Sarah Daijogo and Bert L Semler},
  journal={Journal of virology},
  year={2014},
  volume={88 6},
  pages={3192-201}
}
UNLABELLED Due to their small genome size, picornaviruses must utilize host proteins to mediate cap-independent translation and viral RNA replication. The host RNA-binding protein poly(rC) binding protein 2 (PCBP2) is involved in both processes in poliovirus infected cells. It has been shown that the viral proteinase 3CD cleaves PCBP2 and contributes to viral translation inhibition. However, cleaved PCBP2 remains active in viral RNA replication. This would suggest that both cleaved and intact… CONTINUE READING

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