Inhibition of polarizing activity in the anterior limb bud is regulated by extracellular factors.

@article{Schaller2001InhibitionOP,
  title={Inhibition of polarizing activity in the anterior limb bud is regulated by extracellular factors.},
  author={Skip Schaller and Ken Muneoka},
  journal={Developmental biology},
  year={2001},
  volume={240 2},
  pages={443-56}
}
Anterior-posterior patterning of the developing limb is largely viewed as a function of polarizing activity. Recent evidence in polydactylous mutants, however, indicates that development of proper pattern also requires the involvement of inhibitory pathways in the anterior limb that prevent secondary polarizing zone formation, thus limiting the number of digits produced. We report the novel finding that grafts of extracellular matrix from the Mouse Posterior Limb Bud-4 cell line can induce… CONTINUE READING