Inhibition of pokeweed antiviral protein (PAP) by turnip mosaic virus genome-linked protein (VPg).

@article{Domashevskiy2012InhibitionOP,
  title={Inhibition of pokeweed antiviral protein (PAP) by turnip mosaic virus genome-linked protein (VPg).},
  author={Artem V Domashevskiy and Hiroshi Miyoshi and Dixie J Goss},
  journal={The Journal of biological chemistry},
  year={2012},
  volume={287 35},
  pages={
          29729-38
        }
}
Pokeweed antiviral protein (PAP) from Phytolacca americana is a ribosome-inactivating protein (RIP) and an RNA N-glycosidase that removes specific purine residues from the sarcin/ricin loop of large rRNA, arresting protein synthesis at the translocation step. PAP is also a cap-binding protein and is a potent antiviral agent against many plant, animal, and human viruses. To elucidate the mechanism of RNA depurination, and to understand how PAP recognizes and targets various RNAs, the… CONTINUE READING
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