Inhibition of platelet function by organic nitrate vasodilators.

@article{Schafer1980InhibitionOP,
  title={Inhibition of platelet function by organic nitrate vasodilators.},
  author={A. Schafer and R. Alexander and R. Handin},
  journal={Blood},
  year={1980},
  volume={55 4},
  pages={
          649-54
        }
}
  • A. Schafer, R. Alexander, R. Handin
  • Published 1980
  • Medicine
  • Blood
    • There is evidence that platelet activation in the coronary circulation may be important in the pathogenesis of myocardial ischemia. Since organic nitrate vasodilators are commonly used in coronary artery disease, we have studied the in vitro effects of these drugs on platelet function. Nitroglycerin, isosorbide dinitrate, and their biotransformation product, inorganic nitrite, inhibited platelet aggregation with collagen, epinephrine, arachidonate, and ionophore, and blocked both primary and… CONTINUE READING
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