Inhibition of platelet function: does it offer a chance of better cancer progression control?

@article{Sierko2007InhibitionOP,
  title={Inhibition of platelet function: does it offer a chance of better cancer progression control?},
  author={Ewa Sierko and Marek Zbigniew Wojtukiewicz},
  journal={Seminars in thrombosis and hemostasis},
  year={2007},
  volume={33 7},
  pages={712-21}
}
Thrombocytosis is frequently (10 to 57%) observed in cancer patients. Although the mechanisms underlying thrombocytosis are not yet fully elucidated, tumor-derived factors with thrombopoietin-like activity, growth factors, platelet-derived microparticles, and factors released from bone marrow endothelial cells as well as growth factors secreted by megakaryocytes (acting via an autocrine loop) are claimed to influence this process. The course of cancer is strongly associated with hypercoagulable… CONTINUE READING

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