Inhibition of platelet-derived growth factor-mediated signal transduction and tumor growth by N-[4-(trifluoromethyl)-phenyl]5-methylisoxazole-4-carboxamide.

@article{Shawver1997InhibitionOP,
  title={Inhibition of platelet-derived growth factor-mediated signal transduction and tumor growth by N-[4-(trifluoromethyl)-phenyl]5-methylisoxazole-4-carboxamide.},
  author={Laura K. Shawver and D. P. Schwartz and Elizabeth Mann and Hua Chen and J Tsai and L Chu and L Taylorson and Monica Longhi and Sandra Meredith and Lucie Germain and Julie S. Jacobs and C Tang and Axel Ullrich and Michael E. Berens and Evan Hersh and Geraldine McMahon and K. Peter Hirth and Tiffanie J Powell},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={1997},
  volume={3 7},
  pages={1167-77}
}
Many reports have cited coexpression of platelet-derived growth factor (PDGF) and its receptors by tumor cells or cells supporting tumor growth, suggesting both autocrine and paracrine mechanisms for PDGF-mediated tumor growth. We found that a small organic molecule, N-[4-(trifluoromethyl)phenyl] 5-methylisoxazole-4-carboxamide (SU101, leflunomide), inhibited PDGF-mediated signaling events, including receptor tyrosine phosphorylation, DNA synthesis, cell cycle progression, and cell… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 49 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 43 references

FIk-l as a target for tumor growth inhibition

  • L K.Shawver.
  • Cancer Res.,
  • 1996

The role of endothelial cells in tumor invasion and metastasis

  • Jahroudi, S Greenberger.J.
  • J. Neurooneol.,
  • 1995

Insulin action , diabetogenes . and the cause of Type II

  • C. R. Kahn
  • DIABETES
  • 1994

Similar Papers

Loading similar papers…