Inhibition of platelet-derived growth factor-mediated signal transduction and tumor growth by N-[4-(trifluoromethyl)-phenyl]5-methylisoxazole-4-carboxamide.

  title={Inhibition of platelet-derived growth factor-mediated signal transduction and tumor growth by N-[4-(trifluoromethyl)-phenyl]5-methylisoxazole-4-carboxamide.},
  author={Laura K. Shawver and D. P. Schwartz and Elizabeth Mann and Hua Chen and J Tsai and L Chu and L Taylorson and Monica Longhi and Sandra Meredith and Lucie Germain and Julie S. Jacobs and C Tang and Axel Ullrich and Michael E. Berens and Evan Hersh and Geraldine McMahon and K. Peter Hirth and Tiffanie J Powell},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={3 7},
Many reports have cited coexpression of platelet-derived growth factor (PDGF) and its receptors by tumor cells or cells supporting tumor growth, suggesting both autocrine and paracrine mechanisms for PDGF-mediated tumor growth. We found that a small organic molecule, N-[4-(trifluoromethyl)phenyl] 5-methylisoxazole-4-carboxamide (SU101, leflunomide), inhibited PDGF-mediated signaling events, including receptor tyrosine phosphorylation, DNA synthesis, cell cycle progression, and cell… CONTINUE READING


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