Inhibition of platelet aggregation by polyaspartoyl L-arginine and its mechanism.

@article{Wang2004InhibitionOP,
  title={Inhibition of platelet aggregation by polyaspartoyl L-arginine and its mechanism.},
  author={Yin-ye Wang and Zhi-yu Tang and Min Dong and Xiaoyan Liu and Shi-Qi Peng},
  journal={Acta pharmacologica Sinica},
  year={2004},
  volume={25 4},
  pages={469-73}
}
AIM To observe the oral anti-platelet efficacy and the potential action mechanism of polyaspartoyl L-arginine (PDR), a new L-arginine rich compound. METHODS Platelet aggregation was conducted by Born's method; bleeding time was determined using tail's bleeding time in mice; platelet adhesion was carried out with glass bottle method; nitric oxide (NO) was tested with Griess's method; and cAMP, thromboxane B(2) (TXB(2)) and 6-keto-PGF(1 alpha ) were assessed with commercial kits. RESULTS The… CONTINUE READING
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