Inhibition of platelet aggregation by low concentrations of sodium fluoride. Significance of the intracellular calcium ion concentration.

@article{Kondo1991InhibitionOP,
  title={Inhibition of platelet aggregation by low concentrations of sodium fluoride. Significance of the intracellular calcium ion concentration.},
  author={Kazuhiro Kondo and Chieko Kitada and A. Yoshioka and Hiroshi Sakane and Terutoshi Kokawa and Kojiro Yasunaga},
  journal={International journal of hematology},
  year={1991},
  volume={54 5},
  pages={411-7}
}
Sodium fluoride activates platelets but its mechanism of action has not yet been completely identified. We examined the effect of a low concentration of sodium fluoride (which could not cause aggregation) on thrombin-induced changes in the intracellular calcium ion concentration ([Ca2+]i). In the presence of 1 mM extracellular Ca2+, preincubation with a low concentration of sodium fluoride decreased the peak of the thrombin-induced elevation of [Ca2+]i, when measured with aequorin. When [Ca2… CONTINUE READING