Inhibition of platelet aggregation by acyl-CoA thioesters.


The aggregation of platelets induced by ADP, collagen, or epinephrine in human platelet-rich plasma is inhibited by long chain acyl-CoA thioesters. Palmityl-CoA exerts a concentration dependent inhibition of collagen-induced aggregation and of the primary and secondary waves of ADP-induced aggregation. Palmityl-CoA also inhibits the secondary wave of epinephrine-induced aggregation but has no effect on the primary wave. This inhibitory effect of palmityl-CoA can be reversed by addition of excess ADP and cannot be attributed to a detergent action.

Cite this paper

@article{Lin1976InhibitionOP, title={Inhibition of platelet aggregation by acyl-CoA thioesters.}, author={Chia Yun Lin and Bertram H. Lubin and Susan Jane Smith}, journal={Biochimica et biophysica acta}, year={1976}, volume={428 1}, pages={45-55} }