Inhibition of platelet activating factor by ajmaline in platelets: in vitro and in vivo studies.

@article{Rahman1991InhibitionOP,
  title={Inhibition of platelet activating factor by ajmaline in platelets: in vitro and in vivo studies.},
  author={Nik Norulaini Nik Ab Rahman and R U Simjee and Shaheen Faizi and Atta-ur-Rahman and Syed Shahid Ali and Farida Mahmood and Sheikh Arshad Saeed},
  journal={Pakistan journal of pharmaceutical sciences},
  year={1991},
  volume={4 1},
  pages={35-42}
}
The in vitro and in vivo effects of ajmaline and its derivatives on platelet aggregation and platelet-activating factor (PAF) induced death in rabbits was studied. Ajmalinc and acetyl ajmaline selectively inhibited PAF-induced aggregation in a concentration related manner. Weak or no inhibition of aggregation was observed when ADP, collagen or arachidonic acid were used as aggregating agents. Similarly ajmaline or acetyl ajmaline also inhibited the lethal effects of PAF in the rabbit. PAF (8-11… CONTINUE READING