Inhibition of plasminogen activators attenuates the death of differentiated retinal ganglion cells and stabilizes their neurite network in vitro.

@article{Harvey2007InhibitionOP,
  title={Inhibition of plasminogen activators attenuates the death of differentiated retinal ganglion cells and stabilizes their neurite network in vitro.},
  author={Ron{\'e}e Harvey and Shravan K. Chintala},
  journal={Investigative ophthalmology & visual science},
  year={2007},
  volume={48 4},
  pages={
          1884-91
        }
}
PURPOSE Although previous studies have indicated that elevated levels of the tissue plasminogen activator (tPA) and the urokinase plasminogen activator (uPA) associate with the death of retinal ganglion cells (RGCs), it was unclear whether these proteases directly cause cell death. With the use of a transformed and undifferentiated retinal ganglion cell line, RGC-5, which does not express tPA, and by treating this cell line with staurosporine, which induces not only the differentiation of RGC-5… CONTINUE READING

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