Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cancer.

@article{Mashiko2015InhibitionOP,
  title={Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cancer.},
  author={Satsuki Mashiko and Kazuyuki Kitatani and Masafumi Toyoshima and Atsuhiko Ichimura and T M Wardiny Dan and Toshinori Usui and Masumi Ishibashi and Shogo Shigeta and Satoru Nagase and Toshio Miyata and Nobuo Yaegashi},
  journal={Cancer biology & therapy},
  year={2015},
  volume={16 2},
  pages={253-60}
}
Plasminogen activator inhibitor (PAI)-1 is predictive of poor outcome in several types of cancer. The present study investigated the biological role for PAI-1 in ovarian cancer and potential of targeted pharmacotherapeutics. In patients with ovarian cancer, PAI-1 mRNA expression in tumor tissues was positively correlated with poor prognosis. To determine the role of PAI-1 in cell proliferation in ovarian cancer, the effects of PAI-1 inhibition were examined in PAI-1-expressing ovarian cancer… CONTINUE READING

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