Inhibition of plasma membrane monoamine transporters by beta-ketoamphetamines.

  title={Inhibition of plasma membrane monoamine transporters by beta-ketoamphetamines.},
  author={Nicholas V Cozzi and Michael K Sievert and Alexander T. Shulgin and Petra Jacob and Arnold E. Ruoho},
  journal={European journal of pharmacology},
  volume={381 1},
Methcathinone and methylone, the beta-ketone analogues of methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA), respectively, were tested for neurotransmitter uptake inhibition in vitro. The beta-ketones were threefold less potent than the nonketo drugs at inhibiting platelet serotonin accumulation, with IC(50)'s of 34.6+/-4.8 microM and 5.8+/-0.7… CONTINUE READING