Inhibition of plasma-dependent monocyte chemokinesis and cytokine-triggered endothelial activation for neutrophil transmigration by administration of clopidogrel in man.

@article{Dunzendorfer2002InhibitionOP,
  title={Inhibition of plasma-dependent monocyte chemokinesis and cytokine-triggered endothelial activation for neutrophil transmigration by administration of clopidogrel in man.},
  author={St Dunzendorfer and Christina M. Reinisch and Nicole C. Kaneider and Ch Pechlaner and Ch J Wiedermann},
  journal={Acta medica Austriaca},
  year={2002},
  volume={29 3},
  pages={100-6}
}
Mediators released by spontaneously activated platelets may contribute to alterations in endothelial and leukocyte dysfunctions. We investigated the roles of clopidogrel and aspirin in ex vivo endothelial activation for interactions with leukocytes. Eight healthy volunteers received clopidogrel or aspirin for 8 days. Blood samples were taken before, during, and after treatment. Levels of adhesion molecules and platelet-derived mediators in these samples were measured using commercially… CONTINUE READING

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