Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight

@inproceedings{Dimasuay2017InhibitionOP,
  title={Inhibition of placental mTOR signaling provides a link between placental malaria and reduced birthweight},
  author={Kris Genelyn B. Dimasuay and Elizabeth H Aitken and Fredrick J Rosario and Madi Njie and Jocelyn D Glazier and Stephen J Rogerson and Freya J. I. Fowkes and James G Beeson and Theresa L. Powell and T. Jansson and Philippe Boeuf},
  booktitle={BMC medicine},
  year={2017}
}
BACKGROUND Placental Plasmodium falciparum malaria can trigger intervillositis, a local inflammatory response more strongly associated with low birthweight than placental malaria infection alone. Fetal growth (and therefore birthweight) is dependent on placental amino acid transport, which is impaired in placental malaria-associated intervillositis. Here, we tested the hypothesis that mechanistic target of rapamycin (mTOR) signaling, a pathway known to regulate amino acid transport, is… CONTINUE READING
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