Inhibition of phosphorylated c-Met in rhabdomyosarcoma cell lines by a small molecule inhibitor SU11274

  title={Inhibition of phosphorylated c-Met in rhabdomyosarcoma cell lines by a small molecule inhibitor SU11274},
  author={Jinxuan Hou and Jixin Dong and Lijun Sun and Liying Geng and Jing Wang and Jialin C Zheng and Yan Li and Julia A. Bridge and Steven H. Hinrichs and Shi-jian Ding},
  booktitle={Journal of Translational Medicine},
c-Met is a receptor tyrosine kinase (RTK) that is over-expressed in a variety of cancers and involved in cell growth, invasion, metastasis and angiogenesis. In this study, we investigated the role of c-Met in rhabdomyosarcoma (RMS) using its small molecule inhibitor SU11274, which has been hypothesized to be a potential therapeutic target for RMS. The expression level of phosphorylated c-Met in RMS cell lines (RD, CW9019 and RH30) and tumor tissues was assessed by phospho-RTK array and… CONTINUE READING


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