Inhibition of phosphorolysis catalyzed by HIV-1 reverse transcriptase is responsible for the synergy found in combinations of 3'-azido-3'-deoxythymidine with nonnucleoside inhibitors.

@article{Cruchaga2005InhibitionOP,
  title={Inhibition of phosphorolysis catalyzed by HIV-1 reverse transcriptase is responsible for the synergy found in combinations of 3'-azido-3'-deoxythymidine with nonnucleoside inhibitors.},
  author={Carlos Cruchaga and Leticia Odriozola and Marieline Andr{\'e}ola and Laura Tarrago-Litvak and Juan Jos{\'e} Mart{\'i}nez-Irujo},
  journal={Biochemistry},
  year={2005},
  volume={44 9},
  pages={3535-46}
}
In spite of the growing attention to the combined chemotherapy in the treatment of AIDS, the molecular mechanisms underlying the antiviral synergy of combinations of reverse transcriptase (RT) inhibitors are in most cases unknown. Most combinations of nonnucleoside inhibitors (NNRTI) with nucleoside analogues synergistically inhibit HIV-1 replication in cell culture, though they fail to show synergy in enzymatic assays. In this work we have examined the mechanisms mediating the synergy in… CONTINUE READING

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