Inhibition of phospholipase C-delta 1 catalytic activity by sphingomyelin.


We measured the ability of sphingomyelin (SPM) to inhibit phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] hydrolysis catalyzed by human phospholipase C-delta 1 (PLC-delta 1) in model membranes and detergent phospholipid mixed micelles. SPM strongly inhibited PLC-delta 1 catalytic activity measured in large unilamellar vesicles (LUVs) composed of egg… (More)


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@article{Scarlata1996InhibitionOP, title={Inhibition of phospholipase C-delta 1 catalytic activity by sphingomyelin.}, author={Suzanne F. Scarlata and Rajesh K. Gupta and Patricia Garcia and H Keach and Syed Sadaqat Shah and Chandana Kasireddy and Robert Bittman and Mario J. Rebecchi}, journal={Biochemistry}, year={1996}, volume={35 47}, pages={14882-8} }