Inhibition of phospholipase C‐β1‐mediated signaling by O‐GlcNAc modification

@article{Kim2006InhibitionOP,
  title={Inhibition of phospholipase C‐$\beta$1‐mediated signaling by O‐GlcNAc modification},
  author={Yun-Hee Kim and Minseok Song and Young-Seok Oh and Kyun Heo and Jung Woong Choi and Ji-man Park and Sun-Hee Kim and Seyoung Lim and Hyug Moo Kwon and Sung Ho Ryu and Pann-Ghill Suh},
  journal={Journal of Cellular Physiology},
  year={2006},
  volume={207}
}
Here we report inhibition of phospholipase C‐β1 (PLC‐β1)‐mediated signaling by post‐translational glycosylation with β‐N‐acetylglucosamine (O‐GlcNAc modification). In C2C12 myoblasts, isoform‐specific knock‐down experiments using siRNA showed that activation of bradykinin (BK) receptor led to stimulation of PLC‐β1 and subsequent intracellular Ca2+ mobilization. In C2C12 myotubes, O‐GlcNAc modification of PLC‐β1 was markedly enhanced in response to treatment with glucosamine (GlcNH2), an… Expand
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