Inhibition of phosphatidylserine synthesis by glutamate, acetylcholine, thapsigargin and ionophore A23187 in glioma C6 cells.

@article{Czarny1992InhibitionOP,
  title={Inhibition of phosphatidylserine synthesis by glutamate, acetylcholine, thapsigargin and ionophore A23187 in glioma C6 cells.},
  author={Małgorzata Czarny and Pawelz Sabała and A Ucieklak and Leszek Kaczmarek and Jolanta Barańska},
  journal={Biochemical and biophysical research communications},
  year={1992},
  volume={186 3},
  pages={1582-7}
}
Phosphatidylserine synthesis was studied in glioma C6 cells with [14C]serine and in the presence or absence of agents which increase the level of [Ca2+]i. It was found that glutamate and acetylcholine inhibited this synthesis by up to 40%, whereas thapsigargin and the ionophore A23187 inhibited by up to 70%. The inhibitory effect of thapsigargin and the A23187 was observed in Ca(2+)-free medium. The data show that the inhibition of this synthesis is caused by the Ca(2+)-depletion from… CONTINUE READING