Inhibition of phosphatidylinositol-3-kinase synergizes with gemcitabine in low-passage tumor cell lines correlating with Bax translocation to the mitochondria

@article{BlancoAparicio2005InhibitionOP,
  title={Inhibition of phosphatidylinositol-3-kinase synergizes with gemcitabine in low-passage tumor cell lines correlating with Bax translocation to the mitochondria},
  author={C. Blanco-Aparicio and B. Peque{\~n}o and V. Moneo and L. Romero and J. Leal and J. Velasco and J. Fominaya and A. Carnero},
  journal={Anti-Cancer Drugs},
  year={2005},
  volume={16},
  pages={977-987}
}
Apoptotic pathways, including the phosphatidylinositol-3-kinase (PI3K)/AKT survival pathway, are altered in most cancer cells in relation to their normal counterparts and these differences may present an excellent therapeutic window. To gain insight into the relevance of the PI3K pathway as a target for drug discovery we generated tumor cell lines from different tumor samples that we maintained at low passage. The characterization of these cell lines indicates that all of them have… Expand
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Inhibiting PI3K as a therapeutic strategy against cancer
Targeting Melanoma with Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors
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