Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis.

@article{Son2009InhibitionOP,
  title={Inhibition of phosphatidylinositol 3-kinase signaling in hepatic stellate cells blocks the progression of hepatic fibrosis.},
  author={G. Bittolo Son and Ian Neil Hines and Jeff Lindquist and Laura W. Schrum and Richard A. Rippe},
  journal={Hepatology},
  year={2009},
  volume={50 5},
  pages={1512-23}
}
UNLABELLED The hepatic stellate cell (HSC) is the primary cell type in the liver responsible for excess collagen deposition during fibrosis. Following a fibrogenic stimulus the cell changes from a quiescent vitamin A-storing cell to an activated cell type associated with increased extracellular matrix synthesis and increased cell proliferation. The phosphatidylinositol 3-kinase (PI3K) signaling pathway has been shown to regulate several aspects of HSC activation in vitro, including collagen… CONTINUE READING

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