Inhibition of phosphatidylinositol 3-kinase amplifies TEGDMA-induced apoptosis in primary human pulp cells.

@article{Spagnuolo2004InhibitionOP,
  title={Inhibition of phosphatidylinositol 3-kinase amplifies TEGDMA-induced apoptosis in primary human pulp cells.},
  author={Gianrico Spagnuolo and Kerstin Galler and Gottfried Schmalz and Claudia Cosentino and Sandro Rengo and Helmut Schweikl},
  journal={Journal of dental research},
  year={2004},
  volume={83 9},
  pages={703-7}
}
Cytotoxicity of triethylene glycol dimethacrylate (TEGDMA), a co-monomer of dental resinous restorative materials, is firmly established in vitro, but the molecular mechanisms are unknown. Here we examined apoptosis and necrosis induced by TEGDMA in human primary pulp cells. The levels of apoptotic and necrotic cell populations differentially increased after exposure to increasing concentrations of TEGDMA. A two-fold increase in the percentage of apoptotic cells was induced by 1 mmol/L TEGDMA… CONTINUE READING