Inhibition of phosphatidylcholine synthesis is not the primary pathway in hexadecylphosphocholine-induced apoptosis.

@article{Sanden2004InhibitionOP,
  title={Inhibition of phosphatidylcholine synthesis is not the primary pathway in hexadecylphosphocholine-induced apoptosis.},
  author={Michiel H M van der Sanden and M. Houweling and D. Duijsings and A. Vaandrager and L. M. V. van Golde},
  journal={Biochimica et biophysica acta},
  year={2004},
  volume={1636 2-3},
  pages={
          99-107
        }
}
The anticancer drug hexadecylphosphocholine (HePC), an alkyl-lysophospholipid analog (ALP), has been shown to induce apoptosis and inhibit the synthesis of phosphatidylcholine (PC) in a number of cell lines. We investigated whether inhibition of PC synthesis plays a major causative role in the induction of apoptosis by HePC. We therefore directly compared the apoptosis caused by HePC in CHO cells to the apoptotic process in CHO-MT58 cells, which contain a genetic defect in PC synthesis. HePC… Expand
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