Inhibition of phosphatidylcholine synthesis induces expression of the endoplasmic reticulum stress and apoptosis-related protein CCAAT/enhancer-binding protein-homologous protein (CHOP/GADD153).

@article{Sanden2003InhibitionOP,
  title={Inhibition of phosphatidylcholine synthesis induces expression of the endoplasmic reticulum stress and apoptosis-related protein CCAAT/enhancer-binding protein-homologous protein (CHOP/GADD153).},
  author={Michiel H M van der Sanden and Martin Houweling and Lambert M G van Golde and Arie B. Vaandrager},
  journal={The Biochemical journal},
  year={2003},
  volume={369 Pt 3},
  pages={643-50}
}
Inhibition of de novo synthesis of phosphatidylcholine (PC) by some anti-cancer drugs such as hexadecylphosphocholine leads to apoptosis in various cell lines. Likewise, in MT58, a mutant Chinese hamster ovary (CHO) cell line containing a thermo-sensitive mutation in CTP:phosphocholine cytidylyltransferase (CT), an important regulatory enzyme in the CDP-choline pathway, inhibition of PC synthesis causes PC depletion. Cellular perturbations like metabolic insults and unfolded proteins can be… CONTINUE READING

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Distinct roles

T. Okada, H. Yoshida, R. Akazawa, M. Negishi, K. Mori
2002

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