Inhibition of phorbol ester-caused synthesis of mouse epidermal ornithine decarboxylase by retinoic acid.

@article{Verma1985InhibitionOP,
  title={Inhibition of phorbol ester-caused synthesis of mouse epidermal ornithine decarboxylase by retinoic acid.},
  author={Ajit K. Verma},
  journal={Biochimica et biophysica acta},
  year={1985},
  volume={846 1},
  pages={109-19}
}
The mechanisms by which topically applied retinoic acid to mouse skin inhibits tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced epidermal ornithine decarboxylase activity were analyzed. Retinoic acid inhibition of the induction of epidermal ornithine decarboxylic activity was not the result of nonspecific cytotoxicity, production of a soluble inhibitor of ornithine decarboxylase, or direct effect on its activity. In addition, inhibition of TPA-caused increased ornithine… CONTINUE READING