Inhibition of peripheral FAAH depresses activities of bladder mechanosensitive nerve fibers of the rat.

@article{Aizawa2014InhibitionOP,
  title={Inhibition of peripheral FAAH depresses activities of bladder mechanosensitive nerve fibers of the rat.},
  author={Naoki Aizawa and Petter Hedlund and Claudius Fuellhase and Hiroki Ito and Yukio Homma and Yasuhiko Igawa},
  journal={The Journal of urology},
  year={2014},
  volume={192 3},
  pages={956-63}
}
PURPOSE FAAH degrades endocannabinoids and fatty acid amides. FAAH inhibition reduces micturition frequency and counteracts bladder overactivity in rats. We studied the effects of the peripherally active selective FAAH inhibitor URB937, and the CB1 and CB2 receptor antagonists rimonabant and SR144528, respectively, on single unit afferent activity of primary bladder afferents in rats. MATERIALS AND METHODS Female Sprague Dawley® rats were anesthetized. Single unit afferent activity of Aδ or C… CONTINUE READING

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