Inhibition of peptidoglycan biosynthesis in gram-positive bacteria by LY146032.

@article{Allen1987InhibitionOP,
  title={Inhibition of peptidoglycan biosynthesis in gram-positive bacteria by LY146032.},
  author={Norris E Allen and J. Nicholas Hobbs and William E. Alborn},
  journal={Antimicrobial agents and chemotherapy},
  year={1987},
  volume={31 7},
  pages={1093-9}
}
LY146032, a cyclic lipopeptide antibiotic, is an inhibitor of cell wall peptidoglycan biosynthesis in gram-positive bacteria. Although LY146032 at relatively high concentrations inhibited the in vitro polymerization of UDP-linked sugar precursors, inhibition of cell wall formation in intact Staphylococcus aureus and Bacillus megaterium cells did not lead to the accumulation of UDP-N-acetyl-muramyl (MurNAc)-peptide(s). Experiments that measured formation of UDP-MurNAc-peptides revealed that… CONTINUE READING