Inhibition of parathormone-stimulated bone resorption by type I interferon.

  title={Inhibition of parathormone-stimulated bone resorption by type I interferon.},
  author={Robert L. Jilka and Joshua W. Hamilton},
  journal={Biochemical and biophysical research communications},
  volume={120 2},
The effect of Type I interferon on bone resorption was studied by measuring its effect on parathormone-stimulated calcium release from neonatal murine calvaria in vitro. A pure human recombinant leukocyte interferon hybrid of the A and D subtypes was used, which has high antiviral activity on mouse cells. Calcium release was inhibited in a dose dependent fashion with 50% inhibition at about 10(-10) M or 600 U/ml, and the inhibition was reversible. The presence of interferon was required before… CONTINUE READING
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