Inhibition of pancreatic protein secretion by ghrelin in the rat

  title={Inhibition of pancreatic protein secretion by ghrelin in the rat},
  author={W. Zhang and M. Chen and X. Chen and Bradley J. Segura and Michael W. Mulholland},
  journal={The Journal of Physiology},
1 The role of ghrelin in the regulation of pancreatic protein secretion was investigated in vivo using anaesthetized rats with pancreatic ductal cannulas, and in isolated pancreatic acinar cells and pancreatic lobules in vitro. 2 In vivo, pancreatic protein output stimulated by CCK‐8 (400 pmol kg−1 h−1) was dose‐dependently inhibited by continuous ghrelin infusion (1.2 and 12 nmol kg−1 h−1) by 45 ± 8 and 84 ± 7 %, respectively. 3 In rats with acute subdiaphragmatic vagotomy, ghrelin (12 nmol kg… 
Ghrelin acts on the dorsal vagal complex to stimulate pancreatic protein secretion.
Circulating gh Relin gains access to the brain stem vagovagal circuitry via the area postrema, which represents the primary target on which peripheral ghrelin may act as an endocrine substance to stimulate pancreatic secretion.
Ghrelin attenuates the development of acute pancreatitis in rat.
Protective effect of ghrelin administration was found to attenuates pancreatic damage in caerulein-induced pancreatitis and the effects of both doses were similar.
Central administration of ghrelin stimulates pancreatic exocrine secretion via the vagus in conscious rats.
Centrally administered ghrelin stimulates pancreatic exocrine secretion through the vagal efferent nerve, and the stimulatory action is independent of gastric acid secretion.
Role of leptin in the control of postprandial pancreatic enzyme secretion.
It is concluded that leptin could take a part in the inhibition of postprandial pancreatic secretion and this effect could be related, at least in part, to the direct action of this peptide on pancreatic acini.
A study of the Effect of Ghrelin on the Regulation of Pancreatic Exocrine Secretion in Male Albino Rats
It is concluded that ghrelin is a potent inhibitor of pancreatic exocrine protein secretion and the mechanism of its action may be directed at the level of the intra pancreatic neurotransmission.
Role of ghrelin in the pancreatic exocrine secretion via mitogen-activated protein kinase signaling in rats
Exogenous ghrelin by i.p. infusion plays a role in the pancreatic exocrine secretion via mitogen-activated protein kinase signaling pathway and four proteins such as Destrin, Anionic trypsin-1, Trypsinogen, and especially eukaryotic translation initiation factor 3 in rat pancreas are investigated.
The ghrelin pentapeptide inhibits the secretion of pancreatic juice in rats.
Pentaghrelin may control exocrine pancreas secretion by affecting duodenal neurohormonal mechanism(s) involving CCK and vagal nerves in rats.
Ghrelin and melatonin in the regulation of pancreatic exocrine secretion and maintaining of integrity.
  • J. Jaworek
  • Biology, Medicine
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
  • 2006
The recent data demonstrate that ghrelin is able to prevent pancreatic inflammatory damage though the activation of central nervous mechanisms leading to the improvement of antioxidative properties of pancreatic tissue.
Brain-gut axis in the modulation of pancreatic enzyme secretion.
Melatonin, leptin or ghrelin, which are released into duodenal lumen by nutrients, stimulate pancreatic enzyme secretion by activation of CCK release and activation of duodeno-pancreatic reflex.


Inhibition of Rat Pancreatic Exocrine Secretion by Neuropeptide Y: Studies In Vivo and In Vitro
In conscious rats with pancreatic ductal cannulas, amylase output stimulated by cholecystokinin octapeptide was dose-dependently inhibited by intravenous NPY infusion and inhibition of pancreatic exocrine secretion by 2-deoxyglucose was observed.
Inhibitory regulation of rat exocrine pancreas by peptide YY and pancreatic polypeptide.
Findings indicate that PYY and PP have multiple actions but preferentially inhibit neurally mediated pancreatic secretion at a preacinar cell locus, possibly at a central site of action.
Ghrelin stimulates gastric acid secretion and motility in rats.
Intravenous administrations of rat ghrelin at 0.8 to 20 microgram/kg dose-dependently increased not only gastric acid secretion measured by a lumen-perfused method, but also gastric motility measured byA miniature balloon method suggest that gh Relin may play a physiological role in the vagal control of gastric function in rats.
Ghrelin acts in the central nervous system to stimulate gastric acid secretion.
The results suggest that ghrelin participates in the central regulation of gastric acid secretion by activating the vagus system, and Intracerebroventricular administration increases food intake and body weight.
Neurohormonal control of pancreatic exocrine secretion
This review highlights the recent advances in knowledge of the neurohormonal regulation of pancreatic exocrine secretion as well as the role of the central nervous system in modulating pancreatic secretion.
Nervous control of gastric and pancreatic secretory response to 2-deoxy-D-glucose in the dog.
Results indicate that intravenous 2-DG is a potent stimulant of gastric acid and pancreatic bicarbonate and protein output; the vagus nerves are the major mediators of the gastric and Pancreas secretory response to 2-dG; and the sympathetic nerve fibers running through the celiac and superior mesenteric ganglia are probably not involved in the mediation of the 2- DG-induced gastric Acid and Pancreatic exocrine secretion.
Ghrelin induces adiposity in rodents
It is proposed that ghrelin, in addition to its role in regulating GH secretion, signals the hypothalamus when an increase in metabolic efficiency is necessary, suggesting an involvement in regulation of energy balance.
A role for ghrelin in the central regulation of feeding
It is shown that ghrelin is involved in the hypothalamic regulation of energy homeostasis and probably has a function in growth regulation by stimulating feeding and release of growth hormone.
Kidney produces a novel acylated peptide, ghrelin
Central effects of a novel acylated peptide, ghrelin, on growth hormone release in rats.
Ghrelin neuron is present in the arcuate nucleus of rat hypothalamus, but its central effect on growth hormone (GH) release has yet to be clarified, and the plasma GH concentration and GH mRNA level in the pituitary in response to central administration of ghrelin is determined.