Inhibition of pancreatic protein secretion by ghrelin in the rat

@article{Zhang2001InhibitionOP,
  title={Inhibition of pancreatic protein secretion by ghrelin in the rat},
  author={W. Zhang and M. Chen and X. Chen and Bradley J. Segura and Michael W. Mulholland},
  journal={The Journal of Physiology},
  year={2001},
  volume={537}
}
1 The role of ghrelin in the regulation of pancreatic protein secretion was investigated in vivo using anaesthetized rats with pancreatic ductal cannulas, and in isolated pancreatic acinar cells and pancreatic lobules in vitro. 2 In vivo, pancreatic protein output stimulated by CCK‐8 (400 pmol kg−1 h−1) was dose‐dependently inhibited by continuous ghrelin infusion (1.2 and 12 nmol kg−1 h−1) by 45 ± 8 and 84 ± 7 %, respectively. 3 In rats with acute subdiaphragmatic vagotomy, ghrelin (12 nmol kg… 
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  • J. Jaworek
  • Biology, Medicine
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
  • 2006
TLDR
The recent data demonstrate that ghrelin is able to prevent pancreatic inflammatory damage though the activation of central nervous mechanisms leading to the improvement of antioxidative properties of pancreatic tissue.
Brain-gut axis in the modulation of pancreatic enzyme secretion.
TLDR
Melatonin, leptin or ghrelin, which are released into duodenal lumen by nutrients, stimulate pancreatic enzyme secretion by activation of CCK release and activation of duodeno-pancreatic reflex.
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