Inhibition of p73 function by Pifithrin-alpha as revealed by studies in zebrafish embryos.

@article{Davidson2008InhibitionOP,
  title={Inhibition of p73 function by Pifithrin-alpha as revealed by studies in zebrafish embryos.},
  author={William R. Davidson and Qing Ren and G Rabe Kari and Ori Kashi and Adam P Dicker and Ulrich Rodeck},
  journal={Cell cycle},
  year={2008},
  volume={7 9},
  pages={
          1224-30
        }
}
The p53 family of proteins contains two members that have been implicated in sensitization of cells and organisms to genotoxic stress, i.e., p53 itself and p73. In vitro, lack of either p53 or p73 can protect certain cell types in the adult organism against death upon exposure to DNA damaging agents. The present study was designed to assess the relative contribution of p53 to radiation resistance of an emerging vertebrate model organism, i.e., zebrafish embryos. Consistent with previous reports… CONTINUE READING

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