Inhibition of p53 tumor suppressor by viral interferon regulatory factor.

@article{Nakamura2001InhibitionOP,
  title={Inhibition of p53 tumor suppressor by viral interferon regulatory factor.},
  author={Hiroyuki Nakamura and Mengtao Li and Jodi L Zarycki and Jae U Jung},
  journal={Journal of virology},
  year={2001},
  volume={75 16},
  pages={
          7572-82
        }
}
The irreversible cell cycle arrest and apoptosis induced by p53 are part of the host surveillance mechanisms for viral infection and tumor induction. Kaposi's sarcoma-associated herpesvirus (KSHV), the most recently discovered human tumor virus, is associated with the pathogenesis of Kaposi's sarcoma, primary effusion lymphoma, and multicentric Castleman's disease. The K9 open reading frame of KSHV encodes a viral interferon (IFN) regulatory factor (vIRF) which functions as a repressor for… CONTINUE READING
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