Inhibition of p38 mitogen activated protein kinase controls airway inflammation in cystic fibrosis.

@article{Raia2005InhibitionOP,
  title={Inhibition of p38 mitogen activated protein kinase controls airway inflammation in cystic fibrosis.},
  author={Valeria Raia and Luigi Maiuri and Carolina Ciacci and Ida Ricciardelli and Loredana Vacca and Salvatore Auricchio and Mariano Cimmino and Marisa Cavaliere and Massimiliano Nardone and Annabelle C{\'e}saro and J Malcolm and Sonia Quaratino and Marco Londei},
  journal={Thorax},
  year={2005},
  volume={60 9},
  pages={773-80}
}
BACKGROUND Cystic fibrosis (CF) airways are characterised by chronic inflammation, increased interleukin (IL)-8 secretion, and neutrophil activation which are considered the principal factors of morbidity and mortality in CF patients. Optimising management of this chronic inflammatory response is therefore a key issue of basic and clinical CF research. Several reports have addressed ways to manage CF airways inflammation, and an attractive therapeutic strategy may be the inhibition of the p38… CONTINUE READING
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