Inhibition of p38 mitogen-activated protein kinase activation in the rostral anterior cingulate cortex attenuates pain-related negative emotion in rats.

@article{Cao2014InhibitionOP,
  title={Inhibition of p38 mitogen-activated protein kinase activation in the rostral anterior cingulate cortex attenuates pain-related negative emotion in rats.},
  author={Hong L Cao and Kai-Kai Zang and Mei Han and Zhi-qi Zhao and Gen-cheng Wu and Yu-qiu Zhang},
  journal={Brain research bulletin},
  year={2014},
  volume={107},
  pages={79-88}
}
The emotional components of pain are far less studied than the sensory components. Previous studies have indicated that the rostral anterior cingulate cortex (rACC) is implicated in the affective response to noxious stimuli. Activation of p38 mitogen-activated protein kinase (MAPK) in the spinal cord has been documented to play an important role in diverse… CONTINUE READING