Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia.

@article{Barone2001InhibitionOP,
  title={Inhibition of p38 mitogen-activated protein kinase provides neuroprotection in cerebral focal ischemia.},
  author={Frank Barone and E. Alexander Irving and Alison M. Ray and John Cho Lee and Shouki Kassis and Sudhesh Kumar and Alison M. Badger and Jeffrey J. Legos and Joseph A. Erhardt and Eliot H. Ohlstein and A Jacqueline Hunter and David C. Harrison and Katie Philpott and Brian Richard Smith and Jerry L. Adams and Andrew A. Parsons},
  journal={Medicinal research reviews},
  year={2001},
  volume={21 2},
  pages={
          129-45
        }
}
Mitogen-activated protein kinases (MAPKs) are involved in many cellular processes. The stress-activated MAPK, p38, has been linked to inflammatory cytokine production and cell death following cellular stress. Here, we demonstrate focal ischemic stroke-induced p38 enzyme activation (i.e., phosphorylation) in the brain. The second generation p38 MAPK inhibitor SB 239063 was identified to exhibit increased kinase selectivity and improved cellular and in vivo activity profiles, and thus was… CONTINUE READING
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