Inhibition of p38 and ERK MAP kinases blocks endotoxin-induced nitric oxide production and differentially modulates cytokine expression.

@article{Kim2004InhibitionOP,
  title={Inhibition of p38 and ERK MAP kinases blocks endotoxin-induced nitric oxide production and differentially modulates cytokine expression.},
  author={Sang Hyun Kim and Jiyoung Kim and Raghubir P. Sharma},
  journal={Pharmacological research},
  year={2004},
  volume={49 5},
  pages={
          433-9
        }
}
Mitogen-activated protein kinases (MAPKs) are thought to have a critical role in lipopolysaccharide (LPS)-induced immune responses but the molecular mechanisms underlying the mediation of these signaling are not clear. The roles of p38 and extracellular signal-regulated kinase (ERK) in the regulation of nitric oxide (NO) and proinflammatory cytokine expression in J774A.1 macrophages in response to LPS were examined. Specific inhibitors for p38 and ERK, SB203580 and PD98059, respectively, were… Expand
The p38 MAPK inhibitor SB203580 differentially modulates LPS-induced interleukin 6 expression in macrophages
Macrophage Deletion of p38α Partially Impairs Lipopolysaccharide-Induced Cellular Activation1
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References

SHOWING 1-10 OF 31 REFERENCES
...
1
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3
4
...