Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor.

@article{Peter2007InhibitionOP,
  title={Inhibition of p38 alpha MAPK rescues cardiomyopathy induced by overexpressed beta 2-adrenergic receptor, but not beta 1-adrenergic receptor.},
  author={Pallavi S Peter and Jennifer E Brady and Lin Yan and Wei Chen and Stefan Engelhardt and Yibin Wang and Junichi Sadoshima and Stephen F. Vatner and Dorothy E. Vatner},
  journal={The Journal of clinical investigation},
  year={2007},
  volume={117 5},
  pages={1335-43}
}
We examined the role of p38alpha MAPK in mediating cardiomyopathy in mice overexpressing beta(1)-adrenergic receptor (beta(1)-AR) or beta(2)-AR by mating them with dominant-negative p38alpha (DNp38alpha) MAPK mice. Both beta(1)-AR and beta(2)-AR Tg mice had enhanced LV ejection fraction (LVEF) as young adults and developed similar cardiomyopathy at 11-15 months, characterized by reduced LVEF, myocyte hypertrophy, fibrosis, and apoptosis. We inhibited p38alpha MAPK by mating beta(1)-AR Tg and… CONTINUE READING

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