Inhibition of p38 MAPK attenuates renal atrophy and fibrosis in a murine renal artery stenosis model.

@article{Wang2013InhibitionOP,
  title={Inhibition of p38 MAPK attenuates renal atrophy and fibrosis in a murine renal artery stenosis model.},
  author={Diping Wang and Gina M Warner and Ping Yin and Bruce E. Knudsen and Jingfei Cheng and Kim A. Butters and Karen R. Lien and Catherine E Gray and Vesna D. Garovic and Lilach Orly Lerman and Stephen C. Textor and Karl A Nath and Robert D. Simari and Joseph P Grande},
  journal={American journal of physiology. Renal physiology},
  year={2013},
  volume={304 7},
  pages={F938-47}
}
Renal artery stenosis (RAS) is an important cause of chronic renal dysfunction. Recent studies have underscored a critical role for CCL2 (MCP-1)-mediated inflammation in the progression of chronic renal damage in RAS and other chronic renal diseases. In vitro studies have implicated p38 MAPK as a critical intermediate for the production of CCL2. However, a potential role of p38 signaling in the development and progression of chronic renal disease in RAS has not been previously defined. We… CONTINUE READING
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