Inhibition of p130cas tyrosine phosphorylation by calyculin A.

@article{Qiu1998InhibitionOP,
  title={Inhibition of p130cas tyrosine phosphorylation by calyculin A.},
  author={W Qiu and Ronald R. Cobb and Wolfgang Scholz},
  journal={Journal of leukocyte biology},
  year={1998},
  volume={63 5},
  pages={631-5}
}
P130cas is a dominant tyrosine phosphorylated protein in v-src-and v-crk-transformed cells. Tyrosine phosphorylation also occurs in response to integrin-mediated cell adhesion. P130cas has a unique structure with multiple SH2 and SH3 binding sites, which makes it a candidate docking protein that might be involved in several signal transduction pathways. Little is known about how p130cas itself is regulated. In this report we present evidence that tyrosine phosphorylated p130cas was rapidly… CONTINUE READING