Inhibition of p-450 aromatase prevents feminisation and induces protection during cysticercosis.

@article{MoralesMontor2002InhibitionOP,
  title={Inhibition of p-450 aromatase prevents feminisation and induces protection during cysticercosis.},
  author={Jorge Morales-Montor and C Hallal-Calleros and Martha C. Romano and Raymond T. Damian},
  journal={International journal for parasitology},
  year={2002},
  volume={32 11},
  pages={1379-87}
}
Cysticercotic male mice undergo an impressive feminisation process, characterised by 200 times increased serum 17beta-estradiol levels while testosterone and dihydrotestosterone are 90% reduced, which results in elevated parasite burden. Administration of Fadrozole (an aromatase inhibitor) in male and female mice suppressed the production of 17beta-estradiol, accompanied with a 70% reduction in parasite burden. This protective effect was associated in male mice with a recovery of the specific… CONTINUE READING

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