Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells.

@article{Bartesaghi2015InhibitionOO,
  title={Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells.},
  author={Stefano Bartesaghi and Vincenzo Graziano and Sara Galavotti and Nick V Henriquez and Joanne Betts and Jayeta Saxena and Valentina Minieri and A Deli and Anna Karlsson and L Miguel Martins and Melania Capasso and Pierluigi Nicotera and Sebastian Brandner and Vincenzo De Laurenzi and Paolo Salomoni},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 4},
  pages={1059-64}
}
Alterations of mitochondrial metabolism and genomic instability have been implicated in tumorigenesis in multiple tissues. High-grade glioma (HGG), one of the most lethal human neoplasms, displays genetic modifications of Krebs cycle components as well as electron transport chain (ETC) alterations. Furthermore, the p53 tumor suppressor, which has emerged as a key regulator of mitochondrial respiration at the expense of glycolysis, is genetically inactivated in a large proportion of HGG cases… CONTINUE READING
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