Inhibition of ovarian, placental, and adrenal steroidogenesis in the rhesus monkey by trilostane.

@article{Schane1979InhibitionOO,
  title={Inhibition of ovarian, placental, and adrenal steroidogenesis in the rhesus monkey by trilostane.},
  author={H. Philip Schane and Gordon O. Potts and John E. Creange},
  journal={Fertility and sterility},
  year={1979},
  volume={32 4},
  pages={
          464-7
        }
}
Trilostane inhibits adrenal, ovarian, and placental steroidogenesis when administered orally to rhesus monkeys. By inhibiting 3 beta-hydroxysteroid dehydrogenase activity, it causes an increase in circulating levels of pregnenolone. Trilostane reverses the stimulation of luteal progesterone production and the delay in onset on menstruation induced by human chorionic gonadotropin. In pregnant monkeys it reduces circulating progesterone levels and is an effective interceptive agent if given for 5… CONTINUE READING
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