Inhibition of outflow cushion mesenchyme formation in retinoic acid-induced complete transposition of the great arteries.

@article{Nakajima1996InhibitionOO,
  title={Inhibition of outflow cushion mesenchyme formation in retinoic acid-induced complete transposition of the great arteries.},
  author={Yasuaki Nakajima and Masae Morishima and Makoto Nakazawa and Kazuo Momma},
  journal={Cardiovascular research},
  year={1996},
  volume={31 Spec No},
  pages={E77-85}
}
OBJECTIVE Endocardial cushion tissue formation, the primordia of valves and septa, is a critical event in cardiac morphogenesis. Maternally administrated all-trans retinoic acid is known to induce complete transposition of the great arteries (TGA) in the mouse embryo. To address the mechanisms of TGA, the effect of retinoic acid on cushion tissue formation was examined. METHODS Using a three-dimensional collagen gel culture model, we performed various types of endothelial-mesenchymal… CONTINUE READING

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