Inhibition of osteocyte apoptosis by fluid flow is mediated by nitric oxide.

@article{Tan2008InhibitionOO,
  title={Inhibition of osteocyte apoptosis by fluid flow is mediated by nitric oxide.},
  author={S. Djien Tan and Astrid D Bakker and C. M. Semeins and Anne Marie Kuijpers-Jagtman and Jenneke Klein-Nulend},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={369 4},
  pages={1150-4}
}
Bone unloading results in osteocyte apoptosis, which attracts osteoclasts leading to bone loss. Loading of bone drives fluid flow over osteocytes which respond by releasing signaling molecules, like nitric oxide (NO), that inhibit osteocyte apoptosis and alter osteoblast and osteoclast activity thereby preventing bone loss. However, which apoptosis-related genes are modulated by loading is unknown. We studied apoptosis-related gene expression in response to pulsating fluid flow (PFF) in… CONTINUE READING

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