Inhibition of osteoclast differentiation and bone resorption by rotenone, through down-regulation of RANKL-induced c-Fos and NFATc1 expression.

@article{Kwak2010InhibitionOO,
  title={Inhibition of osteoclast differentiation and bone resorption by rotenone, through down-regulation of RANKL-induced c-Fos and NFATc1 expression.},
  author={Han Bok Kwak and Byeong Ki Lee and Jaemin Oh and J. H. Yeon and Sik-Won Choi and Hae Joong Cho and Myeung Su Lee and Jeong-joong Kim and Ji-Myung Bae and Seong Hwan Kim and Hun Soo Bucheon Kim},
  journal={Bone},
  year={2010},
  volume={46 3},
  pages={
          724-31
        }
}
Osteoclasts are responsible for bone erosion in diseases as diverse as osteoporosis, periodontitis, and rheumatoid arthritis. Natural plant-derived products have received recent attention as potential therapeutic and preventative drugs in human disease. The effect of rotenone in RANKL-induced osteoclast differentiation was examined in this study. Rotenone inhibited RANKL-mediated osteoclast differentiation in bone marrow macrophages (BMMs) in a dose-dependent manner without any evidence of… CONTINUE READING
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