Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin.

@article{Grossmann2012InhibitionOO,
  title={Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin.},
  author={Tom N Grossmann and Johannes T-H Yeh and Brian Bowman and Qian Chu and Raymond E Moellering and Gregory L. Verdine},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 44},
  pages={17942-7}
}
Aberrant activation of signaling by the Wnt pathway is strongly implicated in the onset and progression of numerous types of cancer. Owing to the persistent dependence of these tumors on Wnt signaling for growth and survival, inhibition of this pathway is considered an attractive mechanism-based therapeutic approach. Oncogenic activation of Wnt signaling can ensue from a variety of distinct aberrations in the signaling pathway, but most share the common feature of causing increased cellular… CONTINUE READING

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